GLANDERS IN THE HUMAN SUBJECT

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Glanders.

JAVMA, Vol 233, No. 4, August 15, 2008 G is a highly contagious bacterial disease of horses, mules, and donkeys that is characterized by respiratory, cutaneous, and lymphatic nodular lesions. The disease is zoonotic, affecting persons in close contact with infected animals or those working with the organism in laboratory settings. Once prevalent worldwide, glanders has been eradicated from most...

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Humoral immune responses in a human case of glanders.

Within 2 months of acquiring glanders, a patient developed 8-, 16-, and 4-fold increases, respectively, in specific IgA, IgG, and IgM serological titers against Burkholderia mallei. Within 14 months of infection, the titers decreased to the baseline. Serum from this patient was also highly reactive against Burkholderia pseudomallei whole cells. Burkholderia mallei whole cells did not react with...

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Bichat guidelines for the clinical management of glanders and melioidosis and bioterrorism-related glanders and melioidosis.

Glanders and melioidosis are two infectious diseases that are caused by Burkholderia mallei and Burkholderia pseudomallei respectively. Infection may be acquired through direct skin contact with contaminated soil or water. Ingestion of such contaminated water or dust is another way of contamination. Glanders and melioidosis have both been studied for weaponisation in several countries in the pa...

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The Histological Lesions of Experimental Glanders

The bacillus of glanders may be so modified in virulence as to produce experimentally lesions differing widely in their histological features. The highly virulent culture causes primary necrosis and disintegration of the tissue followed by the invasion of the injured area by polymorphonuclear leucocytes. The bacilli of moderate virulence give rise to a primary lesion of an acute inflammatory na...

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On the Sero-diagnosis of Glanders

NOTWITHSTANDING the discovery of the glanders bacillus the diagnosis of chronic glanders has always been difficult. Later, mallein came into use, but, since the results obtained therewith did not realize all expectations, new serological methods were introduced. Of late two methods were especially used with success, the complement deviation and the agglutination. In the course of this paper the...

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ژورنال

عنوان ژورنال: Annals of Surgery

سال: 1907

ISSN: 0003-4932

DOI: 10.1097/00000658-190703000-00010